1926. It was on October 3 that a first provisional Minor Seminary started at Peramiho in conjunction with the Central School (the new type of “Higher Education” at the same time introduced by the Government).  Father Severin Hofbauer was the intrepid promoter of this training for priesthood until his death in 1955.

1933. On July l6, the first students began Major Seminary studies, listening to the teaching of philosophy by Father Eberhard Spiess.  Three years later he was seconded by Father John Baptist Wolf, lecturer in Theology.

1940.  On June 27, the present main building of Peramiho Major Seminary was opened.  The major seminarians, who since 1936 had studied at Kigonsera, came here and left their quarters at Kigonsera to the minor seminarians who separated themselves fully from the Central School at Peramiho.

1943.  On July 28, the Christian community of Peramiho celebrated the ordination of its first two priests, Gervas Ntara and Simon Kapinga.  By 2006 the total number of priests who had studied in this Seminary had risen to 536.  Out of this number thirteen are bishops and three abbots.

1968.  On April l6, Peramiho Seminary received an inter-diocesan status, as by then the number of dioceses entrusting it with the training of their seminarians had increased to five, namely Peramiho (Songea), Ndanda (Mtwara), Iringa, Nachingwea and Njombe.  So the Seminary was placed under the joint directorship of the five Bishops concerned.  At the same time, Father J.B. Wolf, the Rector since 1940, retired, and at his place a son of the country, Fr. Stephen Mbunga, was appointed Rector. 

1969.  On May 20, the diocese of Peramiho became Songea diocese.  This then was divided into three dioceses, namely Songea itself, Njombe (1968)  and Diocese of Mbinga (1986).

1973.  On March 19, the then diocese of Ndanda became Mtwara diocese.  This was then divided into two, namely, Mtwara and Lindi dioceses in l986.

1986.  On October 17, the former diocese of Nachingwea became the diocese of TUNDURU-Masasi.

1987.  On November 23, the diocese of Songea became the Archdiocese of Songea, comprising dioceses of Songea itself, Iringa, Njombe, Mtwara, Mbinga, Lindi, Mbeya and TUNDURU-Masasi.  So the Seminary was placed under the joint leadership of eight Bishops concerned.  There were changes, too, in Rectors of the seminary.  The vacancy left by Rev. Fr. Stepehen Mbunga (1968 –1972) was filled by H.E. Magnus Mwalunyungu (1972 – 1975), then H.E. Emmanuel Mapunda (1976 –1980), H.E. Tarcisius Ngalalekumtwa (1981 – 1982), H.G. Norbert Mtega (1982 –1985), Rev. Fr. Sebastian Napachihi (1986 – 1989 R.I.P), Rev. Fr. Serapius Komba ( 1989 –1992 R.I.P.), Rev. Fr. Justin Sapula (1992 – 1994), Rev. Fr. Eberhard Mwageni (1994 –2000) and Rev. Fr. Titus Amigu (2000 - ).